里氏新立克次體IgG免疫熒光試劑盒

Neorickettsia risticii IgG IFA Kit

廣州健侖生物科技有限公司

主要用途：用于檢測馬血清中的里氏新立克次體IgG抗體

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里氏新立克次體IgG免疫熒光試劑盒

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【公司名稱】 廣州健侖生物科技有限公司
【】    楊永漢 
【】 
【騰訊 】 2042552662
【公司地址】 廣州清華科技園創(chuàng)新基地番禺石樓鎮(zhèn)創(chuàng)啟路63號二期2幢101-3室
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總之研究發(fā)現(xiàn)TRAP-1基因敲除小鼠表現(xiàn)出較少的與年齡相關(guān)的病癥包括肥胖，炎癥組織變性和自發(fā)形成的腫瘤等。
在加州大學(xué)圣地亞哥醫(yī)學(xué)院神經(jīng)修復(fù)中心主任、神經(jīng)科學(xué)教授Mark Tuszynski博士和同事們將源自于一名86歲的健康男性的皮膚細胞轉(zhuǎn)化為iPSCs后，研究小組將iPSCs重編程為神經(jīng)元，把這些神經(jīng)元放入到包含一些生長因子的基質(zhì)中，然后研究人員再將它們移植到了脊髓損傷達2周的大鼠體內(nèi)。
3個月后，研究小組在大鼠脊髓中發(fā)現(xiàn)了成熟的神經(jīng)元，神經(jīng)纖維跨越長距離廣泛的生長，通過了損傷組織甚至延伸到了大腦中。盡管移植神經(jīng)元和大鼠神經(jīng)元之間存在大量的，但動物肢體的功能尚未得到恢復(fù)。研究人員指出，幾個iPSC移植物都具有一些抗原抗體，有可能阻斷了有益效應(yīng)。
Tuszynski博士說：“這些結(jié)果表明，內(nèi)在神經(jīng)元機制可以輕易地克服脊髓損傷建立的障礙，將許多的軸突延伸很長的距離，且這些能力甚至在由非常老化的人類細胞重編程的神經(jīng)元中持續(xù)存在。”
Tuszynski和Paul Lu以及合作者們，現(xiàn)正致力于鑒別利用來自患者自身細胞的移植物，轉(zhuǎn)化神經(jīng)干細胞療法用于脊髓損傷患者的途徑。
在人類的健康腸道中，干細胞會不斷地彼此競爭得以生存，而在某一個時間某一個腸道區(qū)域往往只會存在一種特定數(shù)量的干細胞生存下來;然而當研究者調(diào)查早期腫瘤組織中的干細胞時，他們卻發(fā)現(xiàn)隨著干細胞生存競爭的劇烈增加，干細胞的數(shù)量也在相應(yīng)增加，這就明顯揭示了腸癌發(fā)生和干細胞活性之間的關(guān)系。
文章中，研究者利用一種特殊開發(fā)的“工具盒”對人類機體的干細胞進行研究，這種新型工具盒可以隨機測定老化干細胞的突變情況，這種突變情況正表明了干細胞所發(fā)生的行為;在本項研究開展之前，關(guān)于人類腸道干細胞生物學(xué)的分子機制依然是個謎，而在這篇研究報道中研究者就解開了這一謎題;研究者利用小鼠進行試驗，由于小鼠的腸道特性和人類的腸道特性具有明顯的相似性，因此利用小鼠進行研究得到的結(jié)果就可以轉(zhuǎn)化到人類機體中。

In conclusion, the study found that TRAP-1 knockout mice showed less age-related disorders including obesity, inflammatory tissue degeneration and spontaneous formation of tumors.
After Mark Tuszynski, professor of neuroscience at the University of California San Diego School of Medicine's neurorestoratology center and colleagues converted skin cells from an 86-year-old healthy male into iPSCs, the team reprogrammed iPSCs into neurons, The neurons were placed in a matrix containing some of the growth factors, and the researchers then transplanted them into rats that had been injured for up to two weeks.
Three months later, the team found mature neurons in the rat spinal cord, which grew extensively over long distances, damaged tissues and even extended into the brain. Despite the large number of connections between transplanted and rat neurons, the function of animal limbs has not been restored. Researchers pointed out that several iPSC implants have some antigenic antibodies, potentially blocking the beneficial effects.
Tuszynski said: "These results show that intrinsic neuronal mechanisms can easily overcome the barriers established by spinal cord injury, extending many axons over long distances, and these abilities even in neurons reprogrammed by very aged human cells In the persistence. "
Tuszynski and Paul Lu and collaborators are now working on identifying the best ways to use neural stem cell-based therapies for patients with SCI using grafts from their own cells.
In human healthy gut, stem cells constantly compete with each other to survive, and at some point there is often only one specific number of stem cells in one gut area; however, when investigators investigate stem cells in early tumor tissues They found that as the number of stem cells increased with the dramatic increase in competition for stem cell survival, this clearly revealed the relationship between colorectal carcinogenesis and stem cell activity.
In this article, the researchers used a specially developed "toolbox" to study human stem cells. This new toolbox allows for the random determination of mutations in aging stem cells, a mutation that is indicative of the behavior of stem cells. Before the study was carried out, the molecular mechanism of human gut stem cell biology remained a mystery, and in the report, researchers solved the mystery; researchers used mice to test that mice Of the intestinal traits and human intestinal characteristics have obvious similarities, so the results of the study using mice can be transformed into the human body.